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Article

Redesign of an artificial ligase ribozyme based on the analysis of its structural elements.

RNA biology - 1 Jan 2000

Ikawa Yoshiya, Matsumoto Junko, Horie Souta, Inoue Tan

Abstract excerpt

The catalytic and folding properties of "DSL ribozyme" were investigated. This artificial ligase ribozyme was constructed by installing a catalytic unit to a designed self-folding RNA. The self-folding RNA was composed of three helices connected via two tertiary interactions that served as scaffolding in the molecular design. The present analysis revealed that the tertiary interaction between the GAAA loop and...

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Identifiers

PMID: 17114929
DOI: 10.4161/rna.2.4.2302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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