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Article

Construction of new ribozymes requiring short regulator oligonucleotides as a cofactor.

Journal of molecular biology - 23 Jun 2000

Komatsu Y, Yamashita S, Kazama N, Nobuoka K, Ohtsuka E

Abstract excerpt

A hairpin loop and an oligonucleotide bound to the loop form one-half of the pseudoknot structure. We have designed an allosteric hammerhead ribozyme, which is activated by the introduction of this motif by using a short complementary oligonucleotide as a cofactor. Stem II of the hammerhead riboz...

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Source

Identifiers

PMID: 10873448
DOI: 10.1006/jmbi.2000.3825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10873448-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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