Article
Ribozyme-catalyzed transcription of an active ribozyme.
Science (New York, N.Y.) - 8 Apr 2011
Wochner Aniela, Attwater James, Coulson Alan, Holliger Philipp
Abstract excerpt
A critical event in the origin of life is thought to have been the emergence of an RNA molecule capable of replicating a primordial RNA "genome." Here we describe the evolution and engineering of an RNA polymerase ribozyme capable of synthesizing RNAs of up to 95 nucleotides in length. To overcome its sequence dependence, we recombined traits evolved separately in different ribozyme lineages. This yielded a more...
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