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Article

New catalytic structures from an existing ribozyme.

Nature structural & molecular biology - 1 Nov 2005

Curtis Edward A, Bartel David P

Abstract excerpt

Although protein enzymes with new catalytic activities can arise from existing scaffolds, less is known about the origin of ribozymes with new activities. Furthermore, mechanisms by which new macromolecular folds arise are not well characterized for either protein or RNA. Here we investigate how readily ribozymes with new catalytic activities and folds can arise from an existing ribozyme scaffold. Using in vitro...

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Identifiers

PMID: 16228005
DOI: 10.1038/nsmb1003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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