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Article

The secondary structure and sequence optimization of an RNA ligase ribozyme.

Nucleic acids research - 25 Aug 1995

Ekland E H, Bartel D P

Abstract excerpt

In vitro selection can generate functional sequence variants of an RNA structural motif that are useful for comparative analysis. The technique is particularly valuable in cases where natural variation is unavailable or non-existent. We report the extension of this approach to a new extreme--the identification of a 112 nt ribozyme secondary structure imbedded within a 186 nt RNA. A pool of 10(14) variants of an...

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Identifiers

PMID: 7667099
DOI: 10.1093/nar/23.16.3231
PMCID: PMC307182

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