Article
The orientation and molecular movement of a k(+) channel voltage-sensing domain.
Neuron - 30 Oct 2003
Gandhi Chris S, Clark Eliana, Loots Eli, Pralle Arnd, Isacoff Ehud Y
Abstract excerpt
Voltage-gated channels operate through the action of a voltage-sensing domain (membrane segments S1-S4) that controls the conformation of gates located in the pore domain (membrane segments S5-S6). Recent structural studies on the bacterial K(v)AP potassium channel have led to a new model of voltage sensing in which S4 lies in the lipid at the channel periphery and moves through the membrane as a unit with a...
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