Article
Voltage-dependent structural interactions in the Shaker K(+) channel.
The Journal of general physiology - 1 Feb 2000
Tiwari-Woodruff S K, Lin M A, Schulteis C T, Papazian D M
Abstract excerpt
Using a strategy related to intragenic suppression, we previously obtained evidence for structural interactions in the voltage sensor of Shaker K(+) channels between residues E283 in S2 and R368 and R371 in S4 (Tiwari-Woodruff, S.K., C.T. Schulteis, A.F. Mock, and D. M. Papazian. 1997. Biophys. J. 72:1489-1500). Because R368 and R371 are involved in the conformational changes that accompany voltage-dependent...
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