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Article

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.

The Journal of biological chemistry - 12 Dec 2003

Labro Alain J, Raes Adam L, Bellens Iris, Ottschytsch Natacha, Snyders Dirk J

Abstract excerpt

The recent crystallization of a voltage-gated K+ channel has given insight into the structure of these channels but has not resolved the issues of the location and the operation of the gate. The conserved PXP motif in the S6 segment of Shaker channels has been proposed to contribute to the intracellular gating structure. To investigate the role of this motif in the destabilization of the alpha-helix, both...

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Identifiers

PMID: 13679372
DOI: 10.1074/jbc.M306097200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.PMID 13679372Read ↗

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.Semantic proximity Read ↗

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.Semantic proximity Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

Conformational dynamics of the inner pore helix of voltage-gated potassium channels.Semantic proximity Read ↗

Investigating the putative glycine hinge in Shaker potassium channel.Semantic proximity Read ↗

Tail end of the s6 segment: role in permeation in shaker potassium channels.Semantic proximity Read ↗

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.Semantic proximity Read ↗

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Atomic proximity between S4 segment and pore domain in Shaker potassium channels.Semantic proximity Read ↗

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