Article
Atomic proximity between S4 segment and pore domain in Shaker potassium channels.
Neuron - 31 Jul 2003
Lainé Muriel, Lin Meng-chin A, Bannister John P A, Silverman William R, Mock Allan F, Roux Benoit, Papazian Diane M
Abstract excerpt
A recently proposed model for voltage-dependent activation in K+ channels, largely influenced by the KvAP X-ray structure, suggests that S4 is located at the periphery of the channel and moves through the lipid bilayer upon depolarization. To investigate the physical distance between S4 and the pore domain in functional channels in a native membrane environment, we engineered pairs of cysteines, one each in S4...
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