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Article

A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.

Neuron - 1 Feb 1994

McCormack K, Joiner W J, Heinemann S H

Abstract excerpt

In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacological blocker 4-aminopyridine on both the K+ and gating currents of wild-type and mutant Shaker K+ channels. Our results...

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Identifiers

PMID: 8110460
DOI: 10.1016/0896-6273(94)90273-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.PMID 8110460Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.Semantic proximity Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

Voltage-dependent structural interactions in the Shaker K(+) channel.Semantic proximity Read ↗

Differences in gating among amino-terminal variants of Shaker potassium channels.Semantic proximity Read ↗

Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.Semantic proximity Read ↗

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Semantic proximity Read ↗

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

Closing in on the resting state of the Shaker K(+) channel.Semantic proximity Read ↗

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.Semantic proximity Read ↗

Constitutive activation of the Shaker Kv channel.Semantic proximity Read ↗

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