Article
A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.
Neuron - 1 Feb 1994
McCormack K, Joiner W J, Heinemann S H
Abstract excerpt
In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacologic...
Topics
- 4-Aminopyridine
- Animals
- Drosophila
- Electrophysiology
- Gene Rearrangement
- Ion Channel Gating
- Mathematics
- Molecular Conformation
- Mutation
- Potassium Channels