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Article

RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40.

EMBO reports - 1 Sept 2006

Simpson Laura J, Ross Anna-Laura, Szüts Dávid, Alviani Cherry A, Oestergaard Vibe H, Patel Ketan J, Sale Julian E

Abstract excerpt

Ubiquitination of proliferating-cell nuclear antigen (PCNA) at K164 by RAD6/RAD18 has a key role in DNA damage tolerance in yeast. Here, we report on the first genetic study of this modification in a vertebrate cell. As in yeast, mutation of K164 of PCNA to arginine in the avian cell line DT40 re...

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Source

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Identifiers

PMID: 16888649
DOI: 10.1038/sj.embor.7400777
PMCID: PMC1559672

Genes

PCNA
RAD18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16888649-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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