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Article

RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40.

EMBO reports - 1 Sept 2006

Simpson Laura J, Ross Anna-Laura, Szüts Dávid, Alviani Cherry A, Oestergaard Vibe H, Patel Ketan J, Sale Julian E

Abstract excerpt

Ubiquitination of proliferating-cell nuclear antigen (PCNA) at K164 by RAD6/RAD18 has a key role in DNA damage tolerance in yeast. Here, we report on the first genetic study of this modification in a vertebrate cell. As in yeast, mutation of K164 of PCNA to arginine in the avian cell line DT40 results in sensitivity to DNA damage but, by contrast, the DT40 pcnaK164R mutant is more sensitive than the rad18 mutant....

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Source

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Identifiers

PMID: 16888649
DOI: 10.1038/sj.embor.7400777
PMCID: PMC1559672

Genes

PCNA
RAD18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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