Article
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.
DNA repair - 10 Oct 2011
Krijger Peter H L, van den Berk Paul C M, Wit Niek, Langerak Petra, Jansen Jacob G, Reynaud Claude-Agnès, de Wind Niels, Jacobs Heinz
Abstract excerpt
The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase η...
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