Article
Involvement of Rad18 in somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006
Bachl Jürgen, Ertongur Isin, Jungnickel Berit
Abstract excerpt
Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are...
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