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Article

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.

The Journal of experimental medicine - 6 Aug 2007

Langerak Petra, Nygren Anders O H, Krijger Peter H L, van den Berk Paul C M, Jacobs Heinz

Abstract excerpt

B cells use translesion DNA synthesis (TLS) to introduce somatic mutations around genetic lesions caused by activation-induced cytidine deaminase. Monoubiquitination at lysine(164) of proliferating cell nuclear antigen (PCNA(K164)) stimulates TLS. To determine the role of PCNA(K164) modifications in somatic hypermutation, PCNA(K164R) knock-in mice were generated. PCNA(K164R/K164R) mutants are born at a...

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Identifiers

PMID: 17664295
DOI: 10.1084/jem.20070902
PMCID: PMC2118671

Genes

PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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