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Article

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2008

Roa Sergio, Avdievich Elena, Peled Jonathan U, Maccarthy Thomas, Werling Uwe, Kuang Fei Li, Kan Rui, Zhao Chunfang, Bergman Aviv, Cohen Paula E, Edelmann Winfried, Scharff Matthew D

Abstract excerpt

Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding properties of proliferating cell nuclear antigen (PCNA) and ubiquitylation of its residue K164 have been suggested to play an important role organizing the error-prone repair events that contribute to the AID-induced diversification of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18854411
DOI: 10.1073/pnas.0808182105
PMCID: PMC2571010

Genes

PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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