Article
Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.
Cell - 23 Feb 1990
Enoch T, Nurse P
Abstract excerpt
Entry into mitosis in fission yeast is controlled by the p34cdc2 protein kinase, which is activated by cdc25+ and inhibited by wee1+. In "wee" mutants one or the other of these controls is circumvented resulting in advancement of mitosis. We report that dependence of mitosis on DNA synthesis is lost in wee mutants in which cdc25+ control is circumvented either by mutations in cdc2+ or by overproduction of cdc25+....
Topics
- CDC2 Protein Kinase
- Cell Cycle
- Cell Cycle Proteins
- Cell Division
- DNA Replication
- Fungal Proteins
- Genes, Fungal
- Hydroxyurea
- Kinetics
- Mutation
- Phosphoproteins
- Protein Kinases