Article
Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.
Science (New York, N.Y.) - 5 Sept 1997
Furnari B, Rhind N, Russell P
Abstract excerpt
Arrest of the cell cycle at the G2 checkpoint, induced by DNA damage, requires inhibitory phosphorylation of the kinase Cdc2 in both fission yeast and human cells. The kinase Wee1 and the phosphatase Cdc25, which regulate Cdc2 phosphorylation, were evaluated as targets of Chk1, a kinase essential for the checkpoint. Fission yeast cdc2-3w Deltacdc25 cells, which express activated Cdc2 and lack Cdc25, were...
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