Article
Activation of fanconi anemia pathway in cells with re-replicated DNA.
Cell cycle (Georgetown, Tex.) - 1 Oct 2006
Zhu Wenge, Dutta Anindya
Abstract excerpt
To maintain genome stability, the cell has to limit initiation of DNA replication to once per cell cycle. Loss of this control leads to DNA rereplication with repeated firing of replication origins in the same cell cycle. Rereplication generates both ssDNA and double strand breaks, as well as activation of the DNA damage checkpoint. In rereplicated cells, activation of the checkpoint is critical to arrest cells...
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