Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.

Theoretical biology & medical modelling - 18 Sept 2015

Rodríguez Alfredo, Torres Leda, Juárez Ulises, Sosa David, Azpeitia Eugenio, García-de Teresa Benilde, Cortés Edith, Ortíz Rocío, Salazar Ana M, Ostrosky-Wegman Patricia, Mendoza Luis, Frías Sara

Abstract excerpt

BACKGROUND: The FA/BRCA pathway repairs DNA interstrand crosslinks. Mutations in this pathway cause Fanconi anemia (FA), a chromosome instability syndrome with bone marrow failure and cancer predisposition. Upon DNA damage, normal and FA cells inhibit the cell cycle progression, until the G2/M checkpoint is turned off by the checkpoint recovery, which becomes activated when the DNA damage has been repaired....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Densitometry

Share to DNA Damage

Share to DNA Repair

Share to Fanconi Anemia

Share to Gene Regulatory Networks

Share to Mitomycin

Source

Open in PubMed Open full text

Identifiers

PMID: 26385365
DOI: 10.1186/s12976-015-0011-4
PMCID: PMC4575447

Genes

PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.PMID 26385365Read ↗

A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.Semantic proximity Read ↗

Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.Semantic proximity Read ↗

Activation of fanconi anemia pathway in cells with re-replicated DNA.Semantic proximity Read ↗

Cell-cycle checkpoint kinases: checking in on the cell cycle.Semantic proximity Read ↗

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.Semantic proximity Read ↗

DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failuresSemantic proximity Read ↗

Cell cycle control, DNA damage checkpoints and cancer.Semantic proximity Read ↗

The Saccharomyces cerevisiae F-box protein Dia2 is a mediator of S-phase checkpoint recovery from DNA damage.Semantic proximity Read ↗

The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-LinksSemantic proximity Read ↗

The Hammer and the Dance of Cell Cycle ControlSemantic proximity Read ↗

Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signalingSemantic proximity Read ↗

The DNA damage checkpoint: A tale from budding yeastSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.