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Article

How Fanconi anemia proteins promote the four Rs: replication, recombination, repair, and recovery.

Environmental and molecular mutagenesis - 1 Jan 2000

Thompson Larry H, Hinz John M, Yamada N Alice, Jones Nigel J

Abstract excerpt

The genetically complex disease Fanconi anemia (FA) comprises cancer predisposition, developmental defects, and bone marrow failure due to elevated apoptosis. The FA cellular phenotype includes universal sensitivity to DNA crosslinking damage, symptoms of oxidative stress, and reduced mutability at the X-linked HPRT gene. In this review article, we present a new heuristic molecular model that accommodates these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15668941
DOI: 10.1002/em.20109

Genes

FANCA
FANCD2
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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