Article
MTHFR 677C-->T and 1298A-->C polymorphisms: evaluation of maternal genotypic risk and association with level of neural tube defect.
Gynecologic and obstetric investigation - 1 Jan 2007
Dalal Ashwin, Pradhan Mandakini, Tiwari Deepshikha, Behari Sanjay, Singh Uttam, Mallik G K, Das Vinita, Agarwal Sarita
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are common birth defects (1 in 1,000) leading to significant morbidity and mortality. Periconceptional folic acid supplementation helps in prevention of 70% of NTDs. Recently, polymorphisms in genes encoding enzymes of the folate pathway have been implicated in causation of NTDs. Since the closure of neural tube occurs at multiple sites, the etiology of defect at different...
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