Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects.

Journal of neurosurgery. Pediatrics - 1 Oct 2010

Harisha Poomagame Narasimhamurthy, Devi B Indira, Christopher Rita, Kruthika-Vinod Tumkur Puttasiddhappa

Abstract excerpt

OBJECT: Neural tube defects (NTDs) are among the most common congenital malformations worldwide. Their etiology and exact mechanisms of development are incompletely understood. Many enzymes involved in folate metabolism and the genes encoding these enzymes have been studied as candidates in their etiology. A mutation in the methylenetetrahydrofolate reductase (MTHFR) gene--a C-->T transition at nucleotide 677--is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Neural Tube Defects

Share to Polymorphism, Genetic

Share to Prevalence

Share to Risk Factors

Source

Identifiers

PMID: 20887110
DOI: 10.3171/2010.8.PEDS1072

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects.PMID 20887110Read ↗

"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".Semantic proximity Read ↗

MTHFR 677C-->T and 1298A-->C polymorphisms: evaluation of maternal genotypic risk and association with level of neural tube defect.Semantic proximity Read ↗

[Meta analysis on the association between parental 5,10-methylenetetrahydrofolate reductase C677T polymorphism and the neural tube defects of their offspring].Semantic proximity Read ↗

Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.Semantic proximity Read ↗

[C677T polymorphism of the methylentetrahydrofolate reductase gene in mothers of children affected with neural tube defects].Semantic proximity Read ↗

Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.Semantic proximity Read ↗

Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population.Semantic proximity Read ↗

MTHFR C677T polymorphism as a risk factor of neural tube defects in Malay: a case control study.Semantic proximity Read ↗

Polymorphisms of 5,10-methylenetetrahydrofolate reductase and cystathionine beta-synthase genes as a risk factor for neural tube defects in Sétif, Algeria.Semantic proximity Read ↗

Variants in MTHFR gene and neural tube defects susceptibility in China.Semantic proximity Read ↗

Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India.Semantic proximity Read ↗

MTHFD1 polymorphism as maternal risk for neural tube defects: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.