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Article

Genetic variation in genes of folate metabolism and neural-tube defect risk.

The Proceedings of the Nutrition Society - 1 May 2006

van der Linden Ivon J M, Afman Lydia A, Heil Sandra G, Blom Henk J

Abstract excerpt

Neural-tube defects (NTD) are common congenital malformations that can lead to severe disability or even death. Periconceptional supplementation with the B-vitamin folic acid has been demonstrated to prevent 50-70% of NTD cases. Since the identification of the first genetic risk factor of NTD, the C677T single-nucleotide polymorphism (SNP) in the methylenetetrahydrofolate reductase (MTHFR) gene, and the...

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Source

Identifiers

PMID: 16672082
DOI: 10.1079/pns2006495

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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