Article
Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2006
Yu Xinhua, Bauer Kristin, Wernhoff Patrik, Koczan Dirk, Möller Steffen, Thiesen Hans-Jürgen, Ibrahim Saleh M
Abstract excerpt
The generation of advanced intercross lines (AIL) is a powerful approach for high-resolution fine mapping of quantitative trait loci (QTLs), because they accumulate much more recombination events compared with conventional F2 intercross and N2 backcross. However, the application of this approach is severely hampered by the requirements of excessive resources to maintain such crosses, i.e., in terms of animal...
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