Article
Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1999
Yang H T, Jirholt J, Svensson L, Sundvall M, Jansson L, Pettersson U, Holmdahl R
Abstract excerpt
The susceptibility to collagen-induced arthritis in the highly susceptible DBA/1 mouse has earlier been shown to be partly controlled by the MHC class II gene Aq. To identify susceptibility loci outside of MHC, we have made crosses between DBA/1 and the less susceptible B10.Q strain, both expressing the MHC class II gene Aq. Analysis of 224 F2 intercross mice with 170 microsatellite markers in a genome-wide scan...
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