Article
Identification of new loci controlling collagen-induced arthritis in mouse using a partial advanced intercross and congenic strains.
Scandinavian journal of immunology - 1 Oct 2008
Popovic M, Ahlqvist E, Rockenbauer E, Bockermann R, Holmdahl R
Abstract excerpt
Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well as a genomic...
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