Article
High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice.
Human molecular genetics - 1 Aug 2011
Ahlqvist Emma, Ekman Diana, Lindvall Therese, Popovic Marjan, Förster Michael, Hultqvist Malin, Klaczkowska Dorota, Teneva Ivanka, Johannesson Martina, Flint Jonathan, Valdar William, Nandakumar Kutty Selva, Holmdahl Rikard
Abstract excerpt
Resolving the genetic basis of complex diseases like rheumatoid arthritis will require knowledge of the corresponding diseases in experimental animals to enable translational functional studies. Mapping of quantitative trait loci in mouse models of arthritis, such as collagen-induced arthritis (CIA), using F(2) crosses has been successful, but can resolve loci only to large chromosomal regions. Using an...
Topics
- Animals
- Arthritis, Experimental
- Arthritis, Rheumatoid
- Crosses, Genetic
- Disease Models, Animal
- Female
- Genotype
- Haplotypes
- Major Histocompatibility Complex
- Male
- Mice
- Quantitative Trait Loci