Article
Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasis.
Arthritis and rheumatism - 1 Aug 2004
Meng Hsiang-Chi, Griffiths Marie M, Remmers Elaine F, Kawahito Yutaka, Li Wentian, Neisa Roberto, Cannon Grant W, Wilder Ronald L, Gulko Pércio S
Abstract excerpt
OBJECTIVE: To identify additional sex-specific and epistatic quantitative trait loci (QTL) regulating collagen-induced arthritis (CIA) severity overall, as well as within different stages during the disease course, in an intercross between major histocompatibility complex-identical inbred rat strains DA/Bkl (susceptible) and ACI/Hsd (resistant). METHODS: Arthritic male (DA x ACI)F2 intercross offspring (n = 143)...
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