Article
Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats.
Arthritis and rheumatism - 1 Dec 1998
Gulko P S, Kawahito Y, Remmers E F, Reese V R, Wang J, Dracheva S V, Ge L, Longman R E, Shepard J S, Cannon G W, Sawitzke A D, Wilder R L, Griffiths M M
Abstract excerpt
OBJECTIVE: To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA). METHODS: We conducted a genome-wide scan to identify CIA regulatory quantitative trait loci (QTL) in an F2 cross between DA (CIA highly susceptible) and ACI (CIA resistant) inbred rats immunized with homologous rat type II collagen (RII)....
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