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Article

Insulin-dependent diabetes loci Idd5 and Idd9 increase sensitivity to experimental autoimmune encephalomyelitis.

Clinical immunology (Orlando, Fla.) - 1 Jan 2000

Mayo Stella, Kohler William, Kumar Vipin, Quinn Anthony

Abstract excerpt

The spontaneous development of autoimmune diabetes in NOD mice suggests that they are unable to establish and maintain immunologic self-tolerance. Congenic NOD mice expressing B10-derived alleles are protected from pancreatic beta cell destruction and autoimmune diabetes. To determine if the B10 alleles in loci Idd5 and Idd9 could influence susceptibility to autoimmunity in other organs, we compared...

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Share to Animals, Congenic
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Share to Mice, Inbred NOD

Share to Myelin-Oligodendrocyte Glycoprotein

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Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 16301001
DOI: 10.1016/j.clim.2005.10.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Insulin-dependent diabetes loci Idd5 and Idd9 increase sensitivity to experimental autoimmune encephalomyelitis.PMID 16301001Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.Semantic proximity Read ↗

The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes.Semantic proximity Read ↗

Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.Semantic proximity Read ↗

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.Semantic proximity Read ↗

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Semantic proximity Read ↗

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Semantic proximity Read ↗

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.Semantic proximity Read ↗

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.Semantic proximity Read ↗

Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.Semantic proximity Read ↗

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