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Article

Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses.

Diabetes - 1 Apr 2011

Driver John P, Chen Yi-Guang, Zhang Weidong, Asrat Seblewongel, Serreze David V

Abstract excerpt

OBJECTIVE: Nominally resistant mouse strains such as C57BL/6 (B6) harbor latent type 1 diabetes susceptibility genes uncovered in outcross to disease-susceptible NOD mice. However, identification of possible recessively acting B6-derived susceptibility genes is limited because very few F2 progeny derived from outcrossing this strain with NOD develop spontaneous autoimmune diabetes. Thus, we assessed whether a...

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Share to CD8-Positive T-Lymphocytes
Share to Chromosomes, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

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Share to Mice, Inbred NOD

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Source

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Identifiers

PMID: 21307079
DOI: 10.2337/db10-0885
PMCID: PMC3064110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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