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Article

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.

Molecular cell - 6 Oct 2006

Yoshimura Michio, Kohzaki Masaoki, Nakamura Jun, Asagoshi Kenjiro, Sonoda Eiichiro, Hou Esther, Prasad Rajendra, Wilson Samuel H, Tano Keizo, Yasui Akira, Lan Li, Seki Mineaki, Wood Richard D, Arakawa Hiroshi, Buerstedde Jean-Marie, Hochegger Helfrid, Okada Takashi, Hiraoka Masahiro, Takeda Shunichi

Abstract excerpt

Base excision repair (BER) plays an essential role in protecting cells from mutagenic base damage caused by oxidative stress, hydrolysis, and environmental factors. POLQ is a DNA polymerase, which appears to be involved in translesion DNA synthesis (TLS) past base damage. We disrupted POLQ, and its homologs HEL308 and POLN in chicken DT40 cells, and also created polq/hel308 and polq/poln double mutants. We found...

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Source

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Identifiers

PMID: 17018297
DOI: 10.1016/j.molcel.2006.07.032
PMCID: PMC1868411

Genes

POLQ
POLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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