Article
R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation.
Oncotarget - 9 Feb 2016
Zhou Ting, Pan Feiyan, Cao Yan, Han Ying, Zhao Jing, Sun Hongfang, Zhou Xiaolong, Wu Xuping, He Lingfeng, Hu Zhigang, Chen Haoyan, Shen Binghui, Guo Zhigang
Abstract excerpt
DNA polymerase β (Pol β) is a key enzyme in DNA base excision repair (BER), a pathway that maintains genome integrity and stability. Pol β mutations have been detected in various types of cancers, suggesting a possible linkage between Pol β mutations and cancer. However, it is not clear whether and how Pol β mutations cause cancer onset and progression. In the current work, we show that a substitution mutation,...
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