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Article

A role for DNA polymerase beta in mutagenic UV lesion bypass.

The Journal of biological chemistry - 20 Dec 2002

Servant Laurence, Cazaux Christophe, Bieth Anne, Iwai Shigenori, Hanaoka Fumio, Hoffmann Jean-Sébastien

Abstract excerpt

We report here that DNA polymerase beta (pol beta), the base excision repair polymerase, is highly expressed in human melanoma tissues, known to be associated with UV radiation exposure. To investigate the potential role of pol beta in UV-induced genetic instability, we analyzed the cellular and molecular effects of excess pol beta. We firstly demonstrated that mammalian cells overexpressing pol beta are...

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PMID: 12388548
DOI: 10.1074/jbc.M207101200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A role for DNA polymerase beta in mutagenic UV lesion bypass.PMID 12388548Read ↗

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A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.Semantic proximity Read ↗

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