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Article

DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.

Nucleic acids research - 1 Feb 2009

Meng Xiao, Zhou Yajing, Zhang Sufang, Lee Ernest Y C, Frick David N, Lee Marietta Y W T

Abstract excerpt

Human DNA polymerase delta (Pol delta4), a key enzyme in chromosomal replication, is a heterotetramer composed of the p125, p50, p68 and p12 subunits. Genotoxic agents such as UV and alkylating chemicals trigger a DNA damage response in which Pol delta4 is converted to a trimer (Pol delta3) by degradation of p12. We show that Pol delta3 has altered enzymatic properties: it is less able to perform translesion...

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Identifiers

PMID: 19074196
DOI: 10.1093/nar/gkn1000
PMCID: PMC2632934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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