Article
DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress.
FEBS letters - 14 Sept 2001
Fréchet M, Canitrot Y, Cazaux C, Hoffmann J S
Abstract excerpt
Oxidative stress has been proposed to be one of the major causes leading to the accumulation of mutation that is associated with the initiation and progression of cancers. Elevated expression of DNA polymerase beta, an event found in many human tumors, has been shown to generate a mutator phenotype. Here, we demonstrated that overexpression of DNA polymerase beta strengthens the mutagenicity of oxidative damages,...
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