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Article

Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.

PLoS genetics - 7 Oct 2010

Hirota Kouji, Sonoda Eiichiro, Kawamoto Takuo, Motegi Akira, Masutani Chikahide, Hanaoka Fumio, Szüts Dávid, Iwai Shigenori, Sale Julian E, Lehmann Alan, Takeda Shunichi

Abstract excerpt

Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions. We provide striking in vivo evidence of the cooperation between DNA polymerase η, which is mutated in the variant form of the cancer predisposition disorder xeroderma...

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Identifiers

PMID: 20949111
DOI: 10.1371/journal.pgen.1001151
PMCID: PMC2951353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions.PMID 20949111Read ↗

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