Article
Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo.
Carcinogenesis - 1 Sept 2002
Cabelof Diane C, Raffoul Julian J, Yanamadala Sunitha, Guo ZhongMao, Heydari Ahmad R
Abstract excerpt
Base excision repair (BER) is the DNA repair pathway primarily responsible for repairing small base modifications and abasic sites caused by normal cellular metabolism or environmental insult. Strong evidence supports the requirement of DNA polymerase beta (beta-pol) in the BER pathway involving single nucleotide gap filling DNA synthesis in mammalian systems. In this study, we examine the relationship between...
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