Article
Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka.
Pigment cell & melanoma research - 1 Mar 2019
Regneri Janine, Klotz Barbara, Wilde Brigitta, Kottler Verena A, Hausmann Michael, Kneitz Susanne, Regensburger Martina, Maurus Katja, Götz Ralph, Lu Yuan, Walter Ronald B, Herpin Amaury, Schartl Manfred
Abstract excerpt
In humans, the CDKN2A locus encodes two transcripts, INK4A and ARF. Inactivation of either one by mutations or epigenetic changes is a frequent signature of malignant melanoma and one of the most relevant entry points for melanomagenesis. To analyze whether cdkn2ab, the fish ortholog of CDKN2A, has a similar function as its human counterpart, we studied its action in fish models for human melanoma. Overexpression...
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