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Article

Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells.

Stem cells (Dayton, Ohio) - 1 May 2008

O'Connor Michael D, Kardel Melanie D, Iosfina Ioulia, Youssef David, Lu Min, Li Michael M, Vercauteren Suzanne, Nagy Andras, Eaves Connie J

Abstract excerpt

Human embryonic stem cells (hESCs) can be maintained in vitro as immortal pluripotent cells but remain responsive to many differentiation-inducing signals. Investigation of the initial critical events involved in differentiation induction would be greatly facilitated if a specific, robust, and quantitative assay for pluripotent hESCs with self-renewal potential were available. Here we describe the results of a...

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PMID: 18276800
DOI: 10.1634/stemcells.2007-0801

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TRA
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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