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Article

Antibody diversification by somatic mutation: from Burnet onwards.

Immunology and cell biology - 1 Feb 2008

Neuberger Michael S

Abstract excerpt

The clonal selection theory proposed by Burnet required a genetic process, for which there was then no precedent, which randomizes the region of the gene(s) responsible for the specification of gamma-globulin molecules. Work over the subsequent half-century substantiated Burnet's speculation, revealing two distinct novel genetic processes. During early development (when Burnet first thought the randomization took...

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Source

Identifiers

PMID: 18180793
DOI: 10.1038/sj.icb.7100160

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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