Article
Antibody diversification by somatic mutation: from Burnet onwards.
Immunology and cell biology - 1 Feb 2008
Neuberger Michael S
Abstract excerpt
The clonal selection theory proposed by Burnet required a genetic process, for which there was then no precedent, which randomizes the region of the gene(s) responsible for the specification of gamma-globulin molecules. Work over the subsequent half-century substantiated Burnet's speculation, rev...
Topics
- Animals
- Antibodies
- Antibody Diversity
- B-Lymphocytes
- Biological Evolution
- Cytidine Deaminase
- DNA
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Humans
- Immunity
- Immunity, Innate
- Immunoglobulin Class Switching
- Immunoglobulin Variable Region
- Models, Immunological
- Mutation
- Somatic Hypermutation, Immunoglobulin
- AICDA (Activation-Induced Cytidine Deaminase)