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Article

Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.

The EMBO journal - 1 Oct 1990

Nocka K, Buck J, Levi E, Besmer P

Abstract excerpt

The c-kit proto-oncogene encodes a transmembrane tyrosine kinase receptor for an unidentified ligand and is allelic with the murine white-spotting locus (W). W mutations affect melanogenesis, gametogenesis and hematopoiesis during development and in adult life. Cellular targets of W mutations in hematopoiesis include distinct cell populations in the erythroid and mast cell lineages as well as stem cells. In the...

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Identifiers

PMID: 1698611
DOI: 10.1002/j.1460-2075.1990.tb07528.x
PMCID: PMC552065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.PMID 1698611Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.Semantic proximity Read ↗

Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells.Semantic proximity Read ↗

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.Semantic proximity Read ↗

The kit ligand: a cell surface molecule altered in steel mutant fibroblasts.Semantic proximity Read ↗

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.Semantic proximity Read ↗

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.Semantic proximity Read ↗

A point mutation in the catalytic domain of c-kit induces growth factor independence, tumorigenicity, and differentiation of mast cellsSemantic proximity Read ↗

A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses.Semantic proximity Read ↗

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