Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells.

doi:10.1111/j.1440-1827.1996.tb03571.x

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Article

Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells.

Pathology international - 1 Dec 1996

Tsujimura T

Abstract excerpt

The c-kit gene is allelic with the dominant spotting (W) locus on mouse chromosome 5 and encodes a receptor tyrosine kinase. The ligand for c-kit receptor is stem cell factor (SCF), which is the principal growth factor for mast cells. The loss-of-function mutations of c-kit receptor affect the de...

Topics

Animals
Cell Survival
Cell Transformation, Neoplastic
Humans
Mast Cells
Mice
Mice, Nude
Mutation
Proto-Oncogene Proteins c-kit
Rats
Receptor Protein-Tyrosine Kinases
Stem Cell Factor

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