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Article

Role of c-kit receptor tyrosine kinase in the development, survival and neoplastic transformation of mast cells.

Pathology international - 1 Dec 1996

Tsujimura T

Abstract excerpt

The c-kit gene is allelic with the dominant spotting (W) locus on mouse chromosome 5 and encodes a receptor tyrosine kinase. The ligand for c-kit receptor is stem cell factor (SCF), which is the principal growth factor for mast cells. The loss-of-function mutations of c-kit receptor affect the development of mast cells, thereby resulting in a depletion of mast cells. The abundant expression of c-kit receptor is...

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Source

Identifiers

PMID: 9110344
DOI: 10.1111/j.1440-1827.1996.tb03571.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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