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Article

The kit ligand: a cell surface molecule altered in steel mutant fibroblasts.

Cell - 5 Oct 1990

Flanagan J G, Leder P

Abstract excerpt

The c-kit proto-oncogene, the gene at the mouse W developmental locus, is one of a substantial group of genes that appear to encode cell surface receptors but for which the ligands are unknown. We have characterized the kit ligand by a generally applicable approach: the receptor extracellular domain was genetically fused to placental alkaline phosphatase, producing a soluble receptor affinity reagent with an...

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Source

Identifiers

PMID: 1698555
DOI: 10.1016/0092-8674(90)90299-t

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The kit ligand: a cell surface molecule altered in steel mutant fibroblasts.PMID 1698555Read ↗

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant.Semantic proximity Read ↗

Steel factor and c-kit protooncogene: genetic lessons in signal transduction.Semantic proximity Read ↗

Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.Semantic proximity Read ↗

Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.Semantic proximity Read ↗

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.Semantic proximity Read ↗

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.Semantic proximity Read ↗

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.Semantic proximity Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

Characterization of the gene-product of the Steel locus.Semantic proximity Read ↗

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.Semantic proximity Read ↗

Biochemical and genetic characterization of multiple splice variants of the Flt3 ligandSemantic proximity Read ↗

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