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Article

A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses.

Journal of immunological methods - 30 Apr 2013

Smrž Daniel, Bandara Geethani, Zhang Shuling, Mock Beverly A, Beaven Michael A, Metcalfe Dean D, Gilfillan Alasdair M

Abstract excerpt

Activation of KIT, by its ligand, stem cell factor (SCF), results in the initiation of signal transduction pathways that influence mast cell survival and proliferation. Activating mutations in KIT have thus been linked to clonal MC proliferation associated with systemic mastocytosis. SCF also modulates MC function by inducing MC chemotaxis and by potentiating antigen (Ag)/IgE-mediated MC degranulation. Thus,...

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Identifiers

PMID: 23357051
DOI: 10.1016/j.jim.2013.01.008
PMCID: PMC3602326

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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