Article
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.
Cell - 5 Oct 1990
Huang E, Nocka K, Beier D R, Chu T Y, Buck J, Lahm H W, Wellner D, Leder P, Besmer P
Abstract excerpt
Mutations at the steel locus (Sl) of the mouse affect the same cellular targets as mutations at the white spotting locus (W), which is allelic with the c-kit proto-oncogene. We show that KL, a hematopoietic growth factor obtained from conditioned medium of BALB/c 3T3 fibroblasts that stimulates the proliferation of mast cells and early erythroid progenitors, specifically binds to the c-kit receptor. The predicted...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chromosome Mapping
- Cloning, Molecular
- DNA
- Genes
- Hematopoietic Cell Growth Factors
- Ligands
- Mice