Invariant chain alters the malignant phenotype of MHC class II+ tumor cells.

Abstract excerpt

T lymphocytes usually recognize endogenously encoded Ag in the context of MHC class I molecules, whereas exogenous Ag is usually presented by MHC class II molecules. In vitro studies in model systems suggest that presentation of endogenous Ag by class II molecules is inhibited by the association of class II with its invariant chain (Ii). In the present study we test this hypothesis in an in vivo system in which...

Topics

• Animals
• Antigens, Differentiation, B-Lymphocyte
• Histocompatibility Antigens Class II
• Mice
• Neoplasms, Experimental
• Phenotype
• Transfection
• Tumor Cells, Cultured