Characterization of defective I-A surface expression in a mixed isotype expressing murine B cell lymphoma: continued expression of E alpha d A beta d despite competition from restored A alpha d A beta d pairs.

doi:10.1093/intimm/4.8.905

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Article

Characterization of defective I-A surface expression in a mixed isotype expressing murine B cell lymphoma: continued expression of E alpha d A beta d despite competition from restored A alpha d A beta d pairs.

International immunology - 1 Aug 1992

Spencer J S, McCormack J E, Kubo R T

Abstract excerpt

The BALB/c-derived mouse B cell lymphoma line, 2PK3, expresses mixed isotype E alpha dA beta d and classical I-E class II molecules on its surface, but normal surface I-A expression is not detectable. Northern blot analysis showed comparable amounts of A alpha mRNA in 2PK3 as compared to another Iad expressing B cell lymphoma, A20, which predominantly expresses I-A and I-E. Sequence analysis of 2PK3 A alpha cDNA...

Topics

Amino Acid Sequence
Animals
Antigen-Presenting Cells
Base Sequence
Cloning, Molecular
Gene Expression
Histocompatibility Antigens Class II
Lymphoma, B-Cell
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Protein Sorting Signals

RNA, Messenger

Transfection

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1329933
DOI: 10.1093/intimm/4.8.905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1329933-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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