Article
Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.
Nature - 1 Jan 2000
Powis S J, Townsend A R, Deverson E V, Bastin J, Butcher G W, Howard J C
Abstract excerpt
In mammalian cells, short peptides derived from intracellular proteins are displayed on the cell membrane associated with class I molecules of the major histocompatibility complex (MHC). The surface presentation of class I-peptide complexes presumably alerts the immune system to intracellular viral protein synthesis. Peptides derived from the cytosol must reach the cisternae of the endoplasmic reticulum where...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Cell Line
- Cells, Cultured
- Cloning, Molecular