Article
Endogenous Ig production in mu transgenic mice. I. Allelic exclusion at the level of expression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1993
Imanishi-Kari T, Bandyopadhay S, Busto P, Huang C A
Abstract excerpt
Our findings indicate that allelic exclusion is maintained in B cells that successfully rearrange and express and endogenous H chain gene, despite carrying a functionally rearranged H chain transgene (17.2.25 mu a). Cloned hybridomas having a functionally rearranged endogenous H chain gene as wel...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Gene Expression
- Gene Rearrangement
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulins
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data