Article
Endogenous Ig production in mu transgenic mice. I. Allelic exclusion at the level of expression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1993
Imanishi-Kari T, Bandyopadhay S, Busto P, Huang C A
Abstract excerpt
Our findings indicate that allelic exclusion is maintained in B cells that successfully rearrange and express and endogenous H chain gene, despite carrying a functionally rearranged H chain transgene (17.2.25 mu a). Cloned hybridomas having a functionally rearranged endogenous H chain gene as well as the transgene produce only endogenous gene products. Some of these hybridoma cultures, upon continuous growth,...
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